Instructions: Select NCCN Risk Group to view the corresponding report.
Very Low/Low
Favorable Intermediate
Unfavorable Intermediate
High/Very High
Prognostic Risk
The ArteraAI prognostic risk group explains how aggressive a patient's prostate cancer is. The 10-year risk of distant metastasis is reported as a continuous variable with a binary low- and high-risk categorization. These risk estimates are based on patients receiving standard of care treatment: salvage RT ± ADT.
Comparison to NRG/RTOG O534 and 9601 Patient Cohorts
This visualization shows how this patient's risk score compares to other patients who recurred after prostatectomy and were treated with salvage radiation therapy with or without ADT. This comparison includes all treatment arms of NRG/RTOG O534 and 9601.
Additional Prognostic Endpoints
5-year risk of distant metastasis and 10-year risk of prostate cancer-specific mortality are also reported to support optimized decision-making. These risk estimates are based on patients receiving standard of care treatment: salvage RT ± ADT.
ADT Insights
Based on the MMAI risk group stratification, MMAI High risk patients were likely to benefit more from the addition of ADT to salvage RT whereas MMAI Low risk patients were likely to benefit less from the addition of ADT.
ADT Insights Supplemental Information
In the validation analysis of patients from NRG/RTOG 0534 and 9601 (n=533), men classified as MMAI High experienced a 21% absolute reduction in 10-year DM risk with ADT added to salvage RT (38% vs. 17%), whereas MMAI Low patients did not show a clinically meaningful difference with ADT (10% vs. 8%). Among MMAI High patients, those treated with salvage RT alone had roughly double the risk of DM compared with those receiving ADT + salvage RT (sHR: 2.10, 95% CI: 1.22-3.61, p=0.007), while MMAI Low patients showed no meaningful difference between treatments (sHR: 1.27, 95% CI: 0.59-2.72, p=0.54). These findings highlight the potential of MMAI to stratify patients by risk and guide intensification of salvage therapy. In plots A and B, "RT Only" represents pelvic bed radiation therapy only.
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