Instructions: Select NCCN Risk Group to view the corresponding report.
Very Low/Low
Favorable Intermediate
Unfavorable Intermediate
High/Very High
Prognostic Risk
The ArteraAI prognostic risk group explains how aggressive the patient's prostate cancer is. The
10-year risk of distant metastasis is reported as a continuous variable with a binary low- and high-risk categorization. These risk estimates are based on patients receiving standard of care treatment: salvage RT ± ADT.
Comparison to NRG/RTOG 0534 and 9601 Patient Cohorts
This visualization shows how this patient's risk score
compares to other patients who recurred after prostatectomy and were treated with salvage radiation therapy with
or without ST-ADT. This comparison includes all treatment arms of NRG/RTOG 0534 and 9601.
Additional Prognostic Endpoints
5-year risk of distant metastasis and 10-year risk of prostate cancer-specific
mortality are also reported to support optimized decision-making. These risk estimates are based on patients
receiving standard of care treatment: salvage RT ± ADT.
ST-ADT Insights
Based on the MMAI risk group stratification, MMAI High risk patients were likely to benefit more
from the addition of ST-ADT to salvage RT whereas MMAI Low risk patients were likely to benefit less from the
addition of ST-ADT.
ST-ADT Insights Supplemental Information
In the validation analysis of patients from NRG/RTOG 0534 and 9601
(n=533), men classified as MMAI High experienced a 21% absolute reduction in 10-year DM risk with ST-ADT added
to salvage RT (38% vs. 17%), whereas MMAI Low patients did not show a clinically meaningful difference with
ST-ADT (10% vs. 8%). Among MMAI High patients, those treated with salvage RT alone had roughly double the risk
of DM compared with those receiving ST-ADT + salvage RT (sHR: 2.10, 95% CI: 1.22-3.61, p=0.007), while MMAI Low
patients showed no meaningful difference between treatments (sHR: 1.27, 95% CI: 0.59-2.72, p=0.54). These
findings highlight the potential of MMAI to stratify patients by risk and guide intensification of salvage therapy. In
plots A and B, "RT Only" represents pelvic bed radiation therapy only.
E
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